Full Product Name
PGAM2 Rabbit Polyclonal
Product Gene Name
anti-PGAM2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Phosphoglycerate mutase 2 (muscle)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PGAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PGAM2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PGAM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000281.2
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NCBI GenBank Nucleotide #
NM_000290.3
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UniProt Related Accession #
P15259[Other Products]
Molecular Weight
28,766 Da
NCBI Official Full Name
phosphoglycerate mutase 2
NCBI Official Synonym Full Names
phosphoglycerate mutase 2
NCBI Official Symbol
PGAM2 [Similar Products]
NCBI Official Synonym Symbols
GSD10; PGAMM; PGAM-M
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NCBI Protein Information
phosphoglycerate mutase 2
UniProt Protein Name
Phosphoglycerate mutase 2
UniProt Synonym Protein Names
BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M
Protein Family
Phosphoglycerate mutase
UniProt Gene Name
PGAM2 [Similar Products]
UniProt Synonym Gene Names
PGAMM; PGAM-M [Similar Products]
UniProt Entry Name
PGAM2_HUMAN
NCBI Summary for PGAM2
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]
UniProt Comments for PGAM2
PGAM2: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10). A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase; EC 5.4.2.11; EC 5.4.2.4; Phosphatase (non-protein); EC 3.1.3.13
Chromosomal Location of Human Ortholog: 7p13-p12
Cellular Component: cytosol; nucleus
Molecular Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity; cofactor binding; phosphoglycerate mutase activity
Biological Process: dephosphorylation; gluconeogenesis; glycolysis; Notch signaling pathway; regulation of pentose-phosphate shunt; response to mercury ion; spermatogenesis; striated muscle contraction
Disease: Glycogen Storage Disease X
Research Articles on PGAM2
1. These results reveal a mechanism of PGAM2 regulation and NADPH homeostasis in response to oxidative stress that impacts cell proliferation and tumor growth.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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