Product Name
BMP 10, Polyclonal Antibody
Full Product Name
BMP 10 antibody
Product Synonym Names
Polyclonal BMP 10; Anti-BMP 10; BMP 10; Bone morphogenetic protein 10; BMP -10; BMP-10
Product Gene Name
anti-BMP 10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q4AEG6
Purity/Purification
BMP 10 antibody was purified by affinity purification.
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Concentration
500 ug/ml (lot specific)
Biological Significance
BMPs belong to the TGF superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP 14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development.
Immunogen
BMP 10 antibody was raised in Rabbit using E Coli expressed human BMP-10 as the immunogen.
Preparation and Storage
Store at -20 degree C. For long-term storage, aliquot and freeze at -70 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-BMP 10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BMP 10 antibody
Rabbit polyclonal BMP 10 antibody
Product Categories/Family for anti-BMP 10 antibody
Signal Transduction
Applications Tested/Suitable for anti-BMP 10 antibody
Western Blot (WB)
Application Notes for anti-BMP 10 antibody
WB: 0.5-4 ug/ml
NCBI/Uniprot data below describe general gene information for BMP 10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001026994.1
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NCBI GenBank Nucleotide #
NM_001031824.1
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UniProt Primary Accession #
Q4AEG6
[Other Products]
UniProt Related Accession #
Q4AEG6[Other Products]
Molecular Weight
47,767 Da
NCBI Official Full Name
bone morphogenetic protein 10
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
Bmp10 [Similar Products]
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
UniProt Gene Name
Bmp10 [Similar Products]
UniProt Synonym Gene Names
BMP-10 [Similar Products]
UniProt Entry Name
BMP10_RAT
UniProt Comments for BMP 10
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines ().
Research Articles on BMP 10
1. the present data suggested that BMP-10 may be implicated in CNS pathophysiology after traumatic brain injury
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
