Product Name
BMP-10, Polyclonal Antibody
Full Product Name
BMP-10 Antibody
Product Synonym Names
Bone Morphogenetic Protein 10; Bone Morphogenetic Protein-10
Product Gene Name
anti-BMP-10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95393
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-human BMP-10 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (lot specific)
Immunogen
E. coli expressed human BMP-10
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of anti-BMP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BMP-10 antibody
Background: BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-10 is essential for the proper development of the heart, but is not expressed until after cardiac patterning or looping is completed.
Applications Tested/Suitable for anti-BMP-10 antibody
Western Blot (WB)
Application Notes for anti-BMP-10 antibody
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Recombinant human BMP-10 can be used as positive control.
Testing Data of anti-BMP-10 antibody
NCBI/Uniprot data below describe general gene information for BMP-10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055297.1
[Other Products]
NCBI GenBank Nucleotide #
NM_014482.1
[Other Products]
UniProt Primary Accession #
O95393
[Other Products]
UniProt Secondary Accession #
Q53R17; Q6NTE0[Other Products]
UniProt Related Accession #
O95393[Other Products]
Molecular Weight
48,047 Da
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
BMP10 [Similar Products]
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
UniProt Gene Name
BMP10 [Similar Products]
UniProt Synonym Gene Names
BMP-10 [Similar Products]
UniProt Entry Name
BMP10_HUMAN
NCBI Summary for BMP-10
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP-10
BMP10: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region; Z disc
Molecular Function: receptor serine/threonine kinase binding; protein binding; growth factor activity; telethonin binding; hormone activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: ***** heart development; extracellular matrix organization and biogenesis; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; activin receptor signaling pathway; cardiac muscle cell proliferation; sarcomere organization; regulation of apoptosis; BMP signaling pathway; regulation of MAPKKK cascade; ventricular cardiac muscle morphogenesis; negative regulation of cell growth; cell adhesion; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation
Research Articles on BMP-10
1. BMP10, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP10 signaling may play a pivotal role in disease development.
Precautions
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Disclaimer
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