KIF5A, Polyclonal Antibody

NKHC; MY050; SPG10; D12S1889

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Store at -20 degree C. Avoid freeze/thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-KIF5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.

Western Blot (WB)

WB: 1:1000 - 1:3000

117kDa

kinesin family member 5A

kinesin heavy chain isoform 5A

Kinesin heavy chain isoform 5A

NKHC1; NKHC  [Similar Products]

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

KIF5A: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10). An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the kinesin-like protein family. Kinesin subfamily.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytosol; kinesin complex; membrane

Molecular Function: motor activity; plus-end-directed microtubule motor activity; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; cytoskeleton-dependent intracellular transport; microtubule-based movement; protein localization; retrograde vesicle-mediated transport, Golgi to ER; synaptic transmission; vesicle-mediated transport

Disease: Myoclonus, Intractable, Neonatal; Spastic Paraplegia 10, Autosomal Dominant

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