Product Name
UBIAD1, Polyclonal Antibody
Full Product Name
UBIAD1 Antibody, Biotin conjugated
Product Synonym Names
UbiA prenyltransferase domain-containing protein 1; Transitional epithelial response protein 1; UBIAD1; TERE1
Product Gene Name
anti-UBIAD1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y5Z9
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human UbiA prenyltransferase domain-containing protein 1 protein (1-82AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-UBIAD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-UBIAD1 antibody
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1, 4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Product Categories/Family for anti-UBIAD1 antibody
Epigenetics and Nuclear Signaling; Cancer; Tags & Cell Markers
Applications Tested/Suitable for anti-UBIAD1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for UBIAD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001317279.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001330350.1
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UniProt Primary Accession #
Q9Y5Z9
[Other Products]
UniProt Secondary Accession #
Q53GX3; Q5THD4; B3KQG3[Other Products]
UniProt Related Accession #
Q9Y5Z9[Other Products]
Molecular Weight
19,482 Da
NCBI Official Full Name
ubiA prenyltransferase domain-containing protein 1 isoform 3
NCBI Official Synonym Full Names
UbiA prenyltransferase domain containing 1
NCBI Official Symbol
UBIAD1 [Similar Products]
NCBI Official Synonym Symbols
SCCD; TERE1
[Similar Products]
NCBI Protein Information
ubiA prenyltransferase domain-containing protein 1
UniProt Protein Name
UbiA prenyltransferase domain-containing protein 1
UniProt Synonym Protein Names
Transitional epithelial response protein 1
Protein Family
UbiA prenyltransferase domain-containing protein
UniProt Gene Name
UBIAD1 [Similar Products]
UniProt Synonym Gene Names
TERE1 [Similar Products]
NCBI Summary for UBIAD1
This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008]
UniProt Comments for UBIAD1
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Research Articles on UBIAD1
1. these findings disclose a novel sensing mechanism that allows for stringent metabolic control of intracellular trafficking of UBIAD1, which directly modulates reductase degradation and becomes disrupted in Schnyder corneal dystrophy (SCD).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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