ALDH2, Recombinant Protein

Aldehyde dehydrogenase mitochondrial; ALDH-E2; ALDHI; ALDM; Aldehyde dehydrogenase; mitochondrial Acetaldehyde dehydrogenase 2; Aldehyde dehydrogenase 2 family; Aldehyde dehydrogenase 2 family (mitochondrial); Aldehyde dehydrogenase mitochondrial; ALDH 2; ALDH class 2; ALDH E2; Liver mitochondrial ALDH; MGC1806; Mitochondrial aldehyde dehydrogenase 2; Nucleus encoded mitochondrial aldehyde dehydrogenase 2.

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 90% by SDS-PAGE

Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1mM DTT, 1 mM EDTA, 10% glycerol

1 mg/ml (determined by Absorbance at 280nm) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of ALDH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ALDH2 (Aldehyde dehydrogenase 2 family) belongs to the aldehyde dehydrogenase family which catalyze the chemical transformation from acetaldehyde to acetic acid and is the second enzyme of the major oxidative pathway of alcohol metabolism. There are two major liver isoforms of this enzyme, cytosolic and mitochondrial, and they can be also distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Recombinant human ALDH2 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Redox Proteins

SDS-PAGE

54.5 kDa (501aa), confirmed by MALDI-TOF.

aldehyde dehydrogenase 2 family member

aldehyde dehydrogenase, mitochondrial

Aldehyde dehydrogenase, mitochondrial

ALDM  [Similar Products]

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]

Crabb DW., et al. (1989). J Clin Invest. 83 (1):314-6; Feng Liu., et al. (2002). Plant Physiol. 130 (4):1657-1674;

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