ACCN3, Polyclonal Antibody

Acid-sensing ion channel 3; ASIC3; hASIC3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1; ASIC3; ACCN3; SLNAC1; TNAC1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This ACCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-ASIC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the degenerin/epithelial
sodium channel (DEG/ENaC) superfamily. The members of this family
are amiloride-sensitive sodium channels that contain intracellular
N and C termini, two hydrophobic transmembrane regions, and a large
extracellular loop, which has many cysteine residues with conserved
spacing. The member encoded by this gene is an acid sensor and may
play an important role in the detection of lasting pH changes. In
addition, a heteromeric association between this member and ACCN1
has been observed as proton-gated channels sensitive to gadolinium.
Alternative splicing of this gene generates three transcript
variants encoding distinct isoforms.

Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

ACCN3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ACCN3 antibody detected the ACCN3 protein (arrow).

58905

acid sensing (proton gated) ion channel 3

acid-sensing ion channel 3

Acid-sensing ion channel 3

ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1  [Similar Products]

ASIC3_HUMAN

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; enterobactin transporter activity; cation channel activity; sodium channel activity; PDZ domain binding

Biological Process: detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; response to heat; transport; sensory perception; sensory perception of sour taste; enterobactin transport; response to acidity; detection of temperature stimulus involved in sensory perception of pain; signal transduction; transmembrane transport

Borzan, J., et al. Anesthesiology 113(3):647-654(2010)
Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010) :
Ko, Y.L., et al. J. Hypertens. 26(11):2154-2160(2008)
Su, X., et al. J. Biol. Chem. 281(48):36960-36968(2006)
Jones, N.G., et al. J. Neurosci. 24(48):10974-10979(2004)

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