Product Name
ACCN3 (ASIC3), Polyclonal Antibody
Full Product Name
ACCN3, NT (ASIC3, ACCN3, SLNAC1, TNAC1, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1)
Product Synonym Names
Anti -ACCN3, NT (ASIC3, ACCN3, SLNAC1, TNAC1, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1)
Product Gene Name
anti-ASIC3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (150745379..150749843). Location: 7q35
3D Structure
ModBase 3D Structure for Q9UHC3
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
ACCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ASIC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASIC3 antibody
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.
Product Categories/Family for anti-ASIC3 antibody
Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-ASIC3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ASIC3 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for ASIC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064718.1
[Other Products]
NCBI GenBank Nucleotide #
NM_020322.3
[Other Products]
UniProt Primary Accession #
Q9UHC3
[Other Products]
UniProt Secondary Accession #
O60263; O75906; Q59FN9; Q9UER8; Q9UHC4; B2R9V0[Other Products]
UniProt Related Accession #
Q9UHC3[Other Products]
Molecular Weight
58,905 Da[Similar Products]
NCBI Official Full Name
acid-sensing ion channel 3 isoform c
NCBI Official Synonym Full Names
acid-sensing (proton-gated) ion channel 3
NCBI Official Symbol
ASIC3 [Similar Products]
NCBI Official Synonym Symbols
ACCN3; TNaC1; DRASIC; SLNAC1
[Similar Products]
NCBI Protein Information
acid-sensing ion channel 3; testis sodium channel 1; modulatory subunit of ASIC2a; proton-gated cation channel subunit; amiloride-sensitive cation channel 3, testis; neuronal amiloride-sensitive cation channel 3
UniProt Protein Name
Acid-sensing ion channel 3
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1
Protein Family
Acid-sensing ion channel
UniProt Gene Name
ASIC3 [Similar Products]
UniProt Synonym Gene Names
ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1 [Similar Products]
UniProt Entry Name
ASIC3_HUMAN
NCBI Summary for ASIC3
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
UniProt Comments for ASIC3
ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral; Channel, cation
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; enterobactin transporter activity; cation channel activity; sodium channel activity; PDZ domain binding
Biological Process: detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; transport; response to heat; sensory perception; sensory perception of sour taste; enterobactin transport; response to acidity; detection of temperature stimulus involved in sensory perception of pain; signal transduction; transmembrane transport
Research Articles on ASIC3
1. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
