Product Name
AChRalpha9, Polyclonal Antibody
Full Product Name
AChRalpha9 Polyclonal Antibody
Product Gene Name
anti-AChRalpha9 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UGM1
Other Notes
Small volumes of anti-AChRalpha9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AChRalpha9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060051.2
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NCBI GenBank Nucleotide #
NM_017581.3
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UniProt Primary Accession #
Q9UGM1
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UniProt Secondary Accession #
Q14CY7; Q4W5A2; Q9NYV2[Other Products]
UniProt Related Accession #
Q9UGM1[Other Products]
Molecular Weight
54,807 Da
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-9
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 9 subunit
NCBI Official Symbol
CHRNA9 [Similar Products]
NCBI Official Synonym Symbols
NACHRA9; HSA243342
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NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-9
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-9
UniProt Synonym Protein Names
Nicotinic acetylcholine receptor subunit alpha-9; NACHR alpha-9
UniProt Gene Name
CHRNA9 [Similar Products]
UniProt Synonym Gene Names
NACHRA9; NACHR alpha-9 [Similar Products]
NCBI Summary for AChRalpha9
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the ***** cochlea. [provided by RefSeq, Feb 2012]
UniProt Comments for AChRalpha9
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
Research Articles on AChRalpha9
1. phosphocholine inhibits ion-channel function of ATP receptor P2X7 in monocytic cells via nAChR containing alpha9 and alpha10 subunits.
Precautions
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Disclaimer
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