Activin receptor type-1 (Acvr1), Recombinant Protein

Activin receptor type-1; EC=2.7.11.30; Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Acvr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Acvr1; Acvrlk2

57,195 Da

activin A receptor, type I

activin receptor type-1; SKR1; TSR-I; ACTR-I; ALK2-B; activin receptor type I; activin type I receptor; activin A receptor, type 1; TGF-B superfamily receptor type I; serine/threonine-protein kinase receptor R1

Activin receptor type-1

Acvrlk2; ACTR-I; SKR1; TSR-I  [Similar Products]

ACVR1_RAT

potential transmembrane protein serine kinase that acts as an activin receptor [RGD, Feb 2006]

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Cellular Component: integral to plasma membrane; apical part of cell; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; gastrulation; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; mesoderm development; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; smooth muscle cell differentiation; determination of left/right symmetry; regulation of ossification; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.