Product Name
CALCA, cDNA Clone
Full Product Name
CALCA cDNA Clone
Product Gene Name
CALCA cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggcttcc aaaagttctc ccccttcctg gctctcagca tcttggtcct gttgcaggca ggcagcctcc atgcagcacc attcaggtct gccctggaga gcagcccagc agacccggcc acgctcagtg aggacgaagc gcgcctcctg ctggctgcac tggtgcagga ctatgtgcag atgaaggcca gtgagctgga gcaggagcaa gagagagagg gctccagcct ggacagcccc agatctaagc ggtgcggtaa tctgagtact tgcatgctgg gcacatacac gcaggacttc aacaagtttc acacgttccc ccaaactgca attggggttg gagcacctgg aaagaaaagg gatatgtcca gcgacttgga gagagaccat cgccctcatg ttagcatgcc ccagaatgcc aactaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CALCA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
NCBI Accession #
BC069760
[Other Products]
UniProt Secondary Accession #
Q13935; Q13937; Q52LX7; B7ZL39[Other Products]
UniProt Related Accession #
P01258; P06881[Other Products]
Molecular Weight
13,898 Da
NCBI Official Full Name
Homo sapiens calcitonin-related polypeptide alpha, mRNA
NCBI Official Synonym Full Names
calcitonin related polypeptide alpha
NCBI Official Symbol
CALCA [Similar Products]
NCBI Official Synonym Symbols
CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
[Similar Products]
NCBI Protein Information
calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name
Calcitonin
UniProt Synonym Protein Names
CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP
Protein Family
Calcitonin
UniProt Gene Name
CALCA [Similar Products]
UniProt Synonym Gene Names
CALC1; CCP [Similar Products]
UniProt Entry Name
CALC_HUMAN
NCBI Summary for CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Comments for CALCA
CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular region; extracellular space
Molecular Function: calcitonin receptor binding; identical protein binding; protein binding
Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity
Research Articles on CALCA
1. In absence of other nosocomial infections, early high serum PCT concentrations appear to be a reliable indicator of bacterial CNS infection in patients with external ventricular drains.
Precautions
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Disclaimer
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