ACVR1, Polyclonal Antibody

ACVR1; activin A receptor, type I; ACTRI; ACVRLK2; ALK2; FOP; SKR1; activin A receptor, type II-like kinase 2; activin A type I receptor; hydroxyalkyl-protein kinase; ACVR1 antibody; activin A receptor; type I antibody; ACTRI antibody; ACVRLK2 antibody; ALK2 antibody; FOP antibody; SKR1 antibody; activin A receptor; type II-like kinase 2 antibody; activin A type I receptor antibody; hydroxyalkyl-protein kinase antibody; ACVR1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-ACVR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Testis shows preferential staining of cytoplasm in primary spermatocytes. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Recommended concentration: 0.3-1ug/ml.

(0.3ug/ml) staining of Human Umbilical Cord lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

(4ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

57,153 Da

activin A receptor type 1

activin receptor type-1

Activin receptor type-1

ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I  [Similar Products]

ACVR1_HUMAN

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: activin receptor complex; apical part of cell; integral to plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; metal ion binding; peptide hormone binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; acute inflammatory response; BMP signaling pathway; determination of left/right symmetry; G1/S transition of mitotic cell cycle; gastrulation with mouth forming second; germ cell development; in utero embryonic development; mesoderm formation; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; neural crest cell migration; patterning of blood vessels; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; smooth muscle cell differentiation; transforming growth factor beta receptor signaling pathway

Disease: Fibrodysplasia Ossificans Progressiva

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