CDCP1, Polyclonal Antibody

Anti-CDCP1 Antibody (N-Terminus) IHC-plus; CDCP1; CD318 antigen; Membrane glycoprotein gp140; SIMA135; TRASK; CD318; Human CDCP1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human CDCP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-CDCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CDCP1 (Cub Domain Containing Protein) was isolated by representational difference analysis using extracts from colon carcinoma and normal colon. It is a putative transmembrane protein with three CUB domains and is thought to be involved in cell adhesion or interaction with the extracellular matrix. CDCP1 undergoes phosphorylation on tyrosine and may undergo shedding as the protein has been detected in the lumen of both normal and cancerous colon crypts by IHC.

Immunohistochemistry (IHC - Paraffin)

IHC-P (5 - 10 ug/ml)

Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE)

Human, Liver: Formalin-Fixed Paraffin-Embedded (FFPE)

37,818 Da

CUB domain containing protein 1

CUB domain-containing protein 1; membrane glycoprotein gp140; transmembrane and associated with src kinases; subtractive immunization M plus HEp3-associated 135 kDa protein

CUB domain-containing protein 1

TRASK; SIMA135  [Similar Products]

CDCP1_HUMAN

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: integral to membrane; extracellular region; plasma membrane

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