Full Product Name
CDCP1 Antibody
Product Synonym Names
CD318; SIMA135; TRASK
Product Gene Name
anti-CDCP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of CDCP1
Calculated Molecular Weight: 836aa; 93kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32846 / sc-32844 / sc-32845 / sc-292398
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CDCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CDCP1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CDCP1 antibody
WB: 1:200-1:2000
Testing Data of anti-CDCP1 antibody
NCBI/Uniprot data below describe general gene information for CDCP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_073753.3
[Other Products]
NCBI GenBank Nucleotide #
NM_022842.4
[Other Products]
UniProt Secondary Accession #
Q49UB4; Q6NT71; Q6U9Y2; Q8WU91; Q96QU7; Q9H676; Q9H8C2[Other Products]
UniProt Related Accession #
Q9H5V8[Other Products]
Molecular Weight
37,818 Da
NCBI Official Full Name
CUB domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
CUB domain containing protein 1
NCBI Official Symbol
CDCP1 [Similar Products]
NCBI Official Synonym Symbols
CD318; TRASK; SIMA135
[Similar Products]
NCBI Protein Information
CUB domain-containing protein 1; membrane glycoprotein gp140; subtractive immunization M plus HEp3-associated 135 kDa protein; transmembrane and associated with src kinases
UniProt Protein Name
CUB domain-containing protein 1
UniProt Synonym Protein Names
Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD_antigen: CD318
Protein Family
CUB domain-containing protein
UniProt Gene Name
CDCP1 [Similar Products]
UniProt Synonym Gene Names
TRASK; SIMA135 [Similar Products]
UniProt Entry Name
CDCP1_HUMAN
NCBI Summary for CDCP1
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
UniProt Comments for CDCP1
CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: integral to membrane; plasma membrane; extracellular region
Research Articles on CDCP1
1. CDCP1 is an essential regulator of the trafficking and function of MT1-MMP- and invadopodia-mediated invasion of cancer cells.
Precautions
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Disclaimer
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