DAB2IP, Polyclonal Antibody

AF9Q34; AIP1; DIP1/2; FLJ39072; KIAA1743

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-DAB2IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

WB: 1:500-1:5000

125,041 Da

DAB2 interacting protein

disabled homolog 2-interacting protein; ASK-interacting protein 1; ASK1-interacting protein 1; DAB2 interaction protein; DOC-2/DAB2 interactive protein; nGAP-like protein

Disabled homolog 2-interacting protein

AF9Q34; AIP1; KIAA1743; DAB2 interaction protein; DAB2-interacting protein; AIP-1  [Similar Products]

DAB2P_HUMAN

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP: Functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK- NF-kappa-B signaling. May act as a tumor suppressor gene. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras; Tumor suppressor

Chromosomal Location of Human Ortholog: 9q33.1-q33.3

Cellular Component: cell soma; endocytic vesicle; axon; cytoplasm; dendrite; plasma membrane

Molecular Function: identical protein binding; protein homodimerization activity; protein phosphatase 2A binding; mitogen-activated protein kinase kinase binding; death receptor binding; mitogen-activated protein kinase kinase kinase binding; protein kinase binding; protein binding; vascular endothelial growth factor receptor 2 binding; protein complex binding; phosphoinositide 3-kinase binding; kinase binding; SH3 domain binding; phosphatidylinositol 3-phosphate binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of JNK activity; negative regulation of MAP kinase activity; regulation of protein heterodimerization activity; positive regulation of apoptosis; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; activation of JNK activity; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase activity; negative regulation of protein amino acid phosphorylation; positive regulation of MAPKKK cascade; regulation of growth; negative regulation of Ras protein signal transduction; regulation of protein complex assembly; angiogenesis; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; layer formation in the cerebral cortex; negative regulation of epithelial cell proliferation; transformed cell apoptosis; negative regulation of vascular endothelial growth factor receptor signaling pathway; lumen formation; negative regulation of I-kappaB kinase/NF-kappaB cascade; cell cycle; negative regulation of angiogenesis; unfolded protein response, activation of signaling protein activity; induction of apoptosis via death domain receptors; cellular protein catabolic process; negative regulation of fibroblast proliferation; inhibition of NF-kappaB transcription factor; negative regulation of toll-like receptor 4 signaling pathway; activation of MAPKKK activity; positive regulation of protein catabolic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; I-kappaB phosphorylation; cell locomotion involved in cerebral cortex radial glia guided migration; neurite morphogenesis; negative regulation of phosphoinositide 3-kinase cascade

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