Product Name
AIOLOS (IKZF3), Blocking Peptide
Full Product Name
AIOLOS Blocking Peptide
Product Synonym Names
ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3
Product Gene Name
IKZF3 blocking peptide
[Similar Products]
AIOLOS peptide (MBS8211544) is used for blocking the activity of AIOLOS antibody (MBS8201313)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UKT9
Species Reactivity
Human, Bovine, Monkey
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of IKZF3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IKZF3 blocking peptide
The peptide is used to block Anti-AIOLOS Antibody reactivity.
Applications Tested/Suitable for IKZF3 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for IKZF3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001244337.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001257408.1
[Other Products]
UniProt Primary Accession #
Q9UKT9
[Other Products]
UniProt Secondary Accession #
Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; B4DVV5[Other Products]
UniProt Related Accession #
Q9UKT9[Other Products]
Molecular Weight
29,973 Da
NCBI Official Full Name
zinc finger protein Aiolos isoform 7
NCBI Official Synonym Full Names
IKAROS family zinc finger 3 (Aiolos)
NCBI Official Symbol
IKZF3 [Similar Products]
NCBI Official Synonym Symbols
AIO; AIOLOS; ZNFN1A3
[Similar Products]
NCBI Protein Information
zinc finger protein Aiolos
UniProt Protein Name
Zinc finger protein Aiolos
UniProt Synonym Protein Names
Ikaros family zinc finger protein 3
Protein Family
Zinc finger protein
UniProt Gene Name
IKZF3 [Similar Products]
UniProt Synonym Gene Names
ZNFN1A3 [Similar Products]
UniProt Entry Name
IKZF3_HUMAN
NCBI Summary for IKZF3
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
UniProt Comments for IKZF3
Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; transcription factor activity
Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; B cell activation; transcription, DNA-dependent; regulation of lymphocyte differentiation; regulation of B cell differentiation; regulation of B cell proliferation; mesoderm development
Research Articles on IKZF3
1. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis.
Precautions
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Disclaimer
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