Product Synonym Names
CMD1N; CMH25; LGMD2G; T-cap; TELE; telethonin
Product Gene Name
anti-TCAP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15273
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human TCAP
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-TCAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TCAP antibody
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
Applications Tested/Suitable for anti-TCAP antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TCAP antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:10-1:100
NCBI/Uniprot data below describe general gene information for TCAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003664.1
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NCBI GenBank Nucleotide #
NM_003673.3
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UniProt Primary Accession #
O15273
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UniProt Secondary Accession #
Q96L27[Other Products]
UniProt Related Accession #
O15273[Other Products]
NCBI Official Full Name
telethonin
NCBI Official Synonym Full Names
titin-cap
NCBI Official Symbol
TCAP [Similar Products]
NCBI Official Synonym Symbols
TELE; CMD1N; CMH25; T-cap; LGMD2G; telethonin
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NCBI Protein Information
telethonin
UniProt Protein Name
Telethonin
UniProt Synonym Protein Names
Titin cap protein
Protein Family
Telethonin
UniProt Gene Name
TCAP [Similar Products]
NCBI Summary for TCAP
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]
UniProt Comments for TCAP
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Research Articles on TCAP
1. based on the crystal structure in which Z1Z2 and telethonin1-90 assemble into a 2:1 complex, a single chain fusion protein was designed, comprising two Z1Z2 modules that are connected by flexible linkers N- and C-terminally of the telethonin1-90. Expression of this fusion protein, named ZTZ, affords high yields of soluble expressed and purified protein
Precautions
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Disclaimer
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