Acvr1, Polyclonal Antibody

Activin receptor type-1; Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L; Acvr1; Acvrlk2; Tgfb1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Mouse Acvr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of mouse Acvr1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.4 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Acvr1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.

Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

Mouse Acvr1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).

Western blot analysis of Acvr1 (arrow) using rabbit polyclonal Mouse Acvr1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Acvr1 gene.

Mouse Acvr1 Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).

Mouse Acvr1 Antibody (Center) (MBS9206850)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Acvr1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

57226

activin A receptor, type 1

activin receptor type-1

Activin receptor type-1

Acvrlk2; Tgfb1; ACTR-I; SKR1; TSR-I  [Similar Products]

ACVR1_MOUSE

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Cellular Component: membrane; apical part of cell; integral to plasma membrane; integral to membrane; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: positive regulation of transcription, DNA-dependent; heart development; activin receptor signaling pathway; gastrulation; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; embryonic development; mesoderm formation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; regulation of ossification; phosphorylation; urogenital system development; G1/S transition of mitotic cell cycle

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