DAB2IP, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Liquid

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-DAB2IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

125,041 Da

DAB2 interacting protein

disabled homolog 2-interacting protein

Disabled homolog 2-interacting protein

AF9Q34; AIP1; KIAA1743; DAB2 interaction protein; DAB2-interacting protein; AIP-1  [Similar Products]

DAB2P_HUMAN

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP: a Ras GTPase-activating protein (GAP) for ARF6 and Ras. Has tumor suppressor activity. Through its interaction with ASK1 disrupts the association of ASK1 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced ASK1-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras; Tumor suppressor

Chromosomal Location of Human Ortholog: 9q33.1-q33.3

Cellular Component: axon; cell soma; cell-cell adherens junction; cytoplasm; cytosol; endocytic vesicle; plasma membrane

Molecular Function: death receptor binding; GTPase activator activity; identical protein binding; kinase binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; phosphatidylinositol 3-phosphate binding; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; SH3 domain binding; vascular endothelial growth factor receptor 2 binding

Biological Process: activation of JNK activity; activation of MAPKKK activity; cell locomotion involved in cerebral cortex radial glia guided migration; cellular protein catabolic process; I-kappaB phosphorylation; induction of apoptosis via death domain receptors; inhibition of NF-kappaB transcription factor; layer formation in the cerebral cortex; lumen formation; MAPKKK cascade; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of MAP kinase activity; negative regulation of phosphoinositide 3-kinase activity; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of Ras protein signal transduction; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vascular endothelial growth factor receptor signaling pathway; neurite morphogenesis; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of GTPase activity; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of protein complex assembly; regulation of protein heterodimerization activity; unfolded protein response, activation of signaling protein activity

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