Full Product Name
CDK10, NT (CDK10, Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE)
Product Synonym Names
Anti -CDK10, NT (CDK10, Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE)
Product Gene Name
anti-CDK10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (89753076..89762772). Location: 16q24
3D Structure
ModBase 3D Structure for Q15131
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~44 amino acids from the N-terminal region of human CDK10.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CDK10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDK10 antibody
CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
Product Categories/Family for anti-CDK10 antibody
Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-CDK10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CDK10 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for CDK10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001153839.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001160367.1
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UniProt Primary Accession #
Q15131
[Other Products]
UniProt Secondary Accession #
Q0VGZ7; Q15130; Q6PJC0; A8MXU6; B7Z420; D3DX82; D3DX83[Other Products]
UniProt Related Accession #
Q15131[Other Products]
Molecular Weight
41,038 Da[Similar Products]
NCBI Official Full Name
cyclin-dependent kinase 10 isoform d
NCBI Official Synonym Full Names
cyclin-dependent kinase 10
NCBI Official Symbol
CDK10 [Similar Products]
NCBI Official Synonym Symbols
PISSLRE
[Similar Products]
NCBI Protein Information
cyclin-dependent kinase 10; CDC2-related protein kinase; cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10; cyclin-dependent kinase related protein; serine/threonine protein kinase PISSLRE; serine/threonine-protein kinase PISSLRE
UniProt Protein Name
Cyclin-dependent kinase 10
UniProt Synonym Protein Names
Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDK10 [Similar Products]
UniProt Entry Name
CDK10_HUMAN
NCBI Summary for CDK10
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for CDK10
CDK10: a CMGC kinase of the CDK family. Plays a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.
Protein type: Kinase, protein; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; CDK family; CDK10 subfamily; CDK/CDK10 subfamily
Chromosomal Location of Human Ortholog: 16q24
Molecular Function: protein binding; cyclin-dependent protein kinase activity; ATP binding
Biological Process: negative regulation of cell proliferation; traversing start control point of mitotic cell cycle; positive regulation of MAPKKK cascade; protein amino acid phosphorylation
Research Articles on CDK10
1. Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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