Product Name
Telethonin (TCAP), Monoclonal Antibody
Full Product Name
Telethonin (Titin Cap Protein, TCAP, T-cap)
Product Synonym Names
Anti -Telethonin (Titin Cap Protein, TCAP, T-cap)
Product Gene Name
anti-TCAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL VQRSPWLMMR MGIHGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG*
Chromosome Location
Chromosome: 17; NC_000017.10 (37821599..37822807). Location: 17q12
3D Structure
ModBase 3D Structure for O15273
Specificity
Recognizes human TCAP.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length recombinant corresponding to aa1-168 from TCAP (AAH13330) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TCAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TCAP antibody
Antibodies; Abs to Cardiac Markers
Applications Tested/Suitable for anti-TCAP antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TCAP antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for TCAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003664.1
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NCBI GenBank Nucleotide #
NM_003673.3
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UniProt Primary Accession #
O15273
[Other Products]
UniProt Secondary Accession #
Q96L27[Other Products]
UniProt Related Accession #
O15273[Other Products]
Molecular Weight
19,052 Da[Similar Products]
NCBI Official Full Name
telethonin
NCBI Official Synonym Full Names
titin-cap
NCBI Official Symbol
TCAP [Similar Products]
NCBI Official Synonym Symbols
TELE; CMD1N; T-cap; LGMD2G; telethonin
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NCBI Protein Information
telethonin; titin cap protein; 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive)
UniProt Protein Name
Telethonin
UniProt Synonym Protein Names
Titin cap protein
Protein Family
Telethonin
UniProt Gene Name
TCAP [Similar Products]
UniProt Entry Name
TELT_HUMAN
NCBI Summary for TCAP
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]
UniProt Comments for TCAP
Telethonin: a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: I band; Z disc; cytosol
Molecular Function: protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding
Biological Process: ***** heart development; cardiac muscle hypertrophy; skeletal muscle contraction; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; sarcomerogenesis; cardiac muscle morphogensis; protein complex assembly; otic vesicle formation; cardiac muscle contraction
Disease: Muscular Dystrophy, Limb-girdle, Type 2g; Cardiomyopathy, Dilated, 1n
Research Articles on TCAP
1. This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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