Product Name
Type-1 angiotensin II receptor (AGTR1), Recombinant Protein
Full Product Name
Recombinant Rabbit Type-1 angiotensin II receptor (AGTR1)
Product Synonym Names
Recombinant Type-1 angiotensin II receptor (AGTR1); Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1
Product Gene Name
AGTR1 recombinant protein
[Similar Products]
Product Synonym Gene Name
AGTR1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
297-359. Fragment at the C-terminal, provide the last complete cytoplasmic domain,
Sequence
LNPLFYGFLG KKFKKYFLQL LKYIPPKAKS HSNLSTKMST LSYRPSDNVS SSSKKPVPCF EVE
Chromosome Location
Chromosome: 14; NC_013682.1 (42512542..42547585). Location: chromosome: 14
3D Structure
ModBase 3D Structure for P34976
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Oryctolagus cuniculus (Rabbit)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AGTR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001075793.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001082324.1
[Other Products]
UniProt Primary Accession #
P34976
[Other Products]
UniProt Related Accession #
P34976[Other Products]
Molecular Weight
40,990 Da[Similar Products]
NCBI Official Full Name
type-1 angiotensin II receptor
NCBI Official Symbol
AGTR1 [Similar Products]
NCBI Official Synonym Symbols
AGTR1A
[Similar Products]
NCBI Protein Information
type-1 angiotensin II receptor; AT1 ANG II receptor; AT1 angiotensin II receptor; angiotensin II type-1 receptor
UniProt Protein Name
Type-1 angiotensin II receptor
UniProt Synonym Protein Names
Angiotensin II type-1 receptor
Protein Family
Type-1 angiotensin II receptor
UniProt Gene Name
AGTR1 [Similar Products]
UniProt Synonym Gene Names
AT1 [Similar Products]
UniProt Entry Name
AGTR1_RABIT
UniProt Comments for AGTR1
Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit structure: Interacts with MAS1. Interacts with ARRB1
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Post-translational modification: C-terminal Ser or Thr residues may be phosphorylated.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on AGTR1
1. Renal AT1R expression was increased by approximately 67% and AT2R expression was decreased by approximately 87% in rabbits with heart failure; however, kidneys from denervated rabbits with heart failure showed a near normalization in the expression of these receptors.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
