Full Product Name
ARSB Antibody
Product Gene Name
anti-ARSB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15848
Other Notes
Small volumes of anti-ARSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-ARSB antibody
Western blot analysis ARSB using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for ARSB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000037.2
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NCBI GenBank Nucleotide #
NM_000046.4
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UniProt Primary Accession #
P15848
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UniProt Secondary Accession #
Q8N322; Q9UDI9; B2RC20[Other Products]
UniProt Related Accession #
P15848[Other Products]
Molecular Weight
45,996 Da
NCBI Official Full Name
arylsulfatase B isoform 1
NCBI Official Synonym Full Names
arylsulfatase B
NCBI Official Symbol
ARSB [Similar Products]
NCBI Official Synonym Symbols
ASB; G4S; MPS6
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NCBI Protein Information
arylsulfatase B
UniProt Protein Name
Arylsulfatase B
UniProt Synonym Protein Names
N-acetylgalactosamine-4-sulfatase; G4S
Protein Family
Arylsulfatase
UniProt Gene Name
ARSB [Similar Products]
UniProt Synonym Gene Names
ASB; G4S [Similar Products]
NCBI Summary for ARSB
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
UniProt Comments for ARSB
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels ().
Research Articles on ARSB
1. A (p.C155Y) and c.1163G>C (p.R388T) mutations, a 13.8-kb deletion encompassing exons 2 and 3, mutation c.479G>A (p.R160Q), and novel c.464G>A (p.C155Y) mutation.">Three novel mutations in ARSB were detected, expanding the mutational spectrum of ARSB causing MPS VI. A compound heterozygous for the c.464G>A (p.C155Y) and c.1163G>C (p.R388T) mutations, a 13.8-kb deletion encompassing exons 2 and 3, mutation c.479G>A (p.R160Q), and novel c.464G>A (p.C155Y) mutation.
Precautions
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Disclaimer
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