Full Product Name
CC2D1A Antibody
Product Gene Name
anti-CC2D1A antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6P1N0
Other Notes
Small volumes of anti-CC2D1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CC2D1A antibody
Primary Antibodies; Epigenetics; Transcription; CC2D1A Antibody
NCBI/Uniprot data below describe general gene information for CC2D1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060191.3
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NCBI GenBank Nucleotide #
NM_017721.4
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UniProt Primary Accession #
Q6P1N0
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UniProt Secondary Accession #
Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1[Other Products]
UniProt Related Accession #
Q6P1N0[Other Products]
Molecular Weight
103,934 Da
NCBI Official Full Name
coiled-coil and C2 domain-containing protein 1A
NCBI Official Synonym Full Names
coiled-coil and C2 domain containing 1A
NCBI Official Symbol
CC2D1A [Similar Products]
NCBI Official Synonym Symbols
MRT3; FREUD-1; Freud-1/Aki1
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NCBI Protein Information
coiled-coil and C2 domain-containing protein 1A
UniProt Protein Name
Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names
Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
Protein Family
Coiled-coil and C2 domain-containing protein
UniProt Gene Name
CC2D1A [Similar Products]
UniProt Synonym Gene Names
AKI1; FRE under dual repression-binding protein 1; Freud-1 [Similar Products]
NCBI Summary for CC2D1A
This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]
UniProt Comments for CC2D1A
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Research Articles on CC2D1A
1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different
Precautions
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Disclaimer
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