Product Name
Polymerase DNA Directed Delta 1 (POLd), Polyclonal Antibody
Full Product Name
APC/CY7-Linked Polyclonal Antibody to Polymerase DNA Directed Delta 1 (POLd)
Product Synonym Names
CDC2; POLD1; DNA polymerase subunit delta p125
Product Gene Name
anti-POLd antibody
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Matching Pairs
Unconjugated Antibody: Polymerase DNA Directed Delta 1 (MBS2032450)
APC-CY7 Conjugated Antibody: Polymerase DNA Directed Delta 1 (POLd) (MBS2067759)
Matching Pairs
APC-CY7 Conjugated Antibody: Polymerase DNA Directed Delta 1 (POLd) (MBS2067759)
Immunogen: Polymerase DNA Directed Delta 1 (MBS2033314)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
POLd (Met41~Phe254)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032450
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-POLd antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-POLd antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for POLd. It may not necessarily be applicable to this product.
NCBI Accession #
AAH08800.1
[Other Products]
UniProt Secondary Accession #
Q8NER3; Q96H98[Other Products]
UniProt Related Accession #
P28340[Other Products]
Molecular Weight
123,631 Da
NCBI Official Full Name
Polymerase (DNA directed), delta 1, catalytic subunit 125kDa
NCBI Official Synonym Full Names
DNA polymerase delta 1, catalytic subunit
NCBI Official Symbol
POLD1 [Similar Products]
NCBI Official Synonym Symbols
CDC2; MDPL; POLD; CRCS10
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NCBI Protein Information
DNA polymerase delta catalytic subunit
UniProt Protein Name
DNA polymerase delta catalytic subunit
UniProt Synonym Protein Names
DNA polymerase subunit delta p125
UniProt Gene Name
POLD1 [Similar Products]
UniProt Synonym Gene Names
POLD [Similar Products]
NCBI Summary for POLd
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
UniProt Comments for POLd
POLD1: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. Belongs to the DNA polymerase type-B family.
Protein type: DNA repair, damage; DNA replication; EC 2.7.7.7; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasm; delta DNA polymerase complex; membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleotide-excision repair complex; nucleus
Molecular Function: 3'-5'-exodeoxyribonuclease activity; chromatin binding; damaged DNA binding; DNA binding; DNA-directed DNA polymerase activity; protein binding
Biological Process: base-excision repair, gap-filling; bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA repair; DNA replication; DNA replication proofreading; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; fatty acid homeostasis; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair
Disease: Colorectal Cancer, Susceptibility To, 10; Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome
Research Articles on POLd
1. study of complete exonuclease domains of POLE and POLD1 in 529 families characterized by presence of familial or early-onset mismatch repair proficient colorectal cancer, and/or APC-negative and MUTYH-negative polyposis; results widen the phenotypic spectrum of the POLE/POLD1-associated syndrome and identify novel pathogenic variants
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
