Product Name
Coiled-coil and C2 domain-containing protein 1A (Cc2d1a), Recombinant Protein
Full Product Name
Recombinant Rat Coiled-coil and C2 domain-containing protein 1A (Cc2d1a) , partial
Product Gene Name
Cc2d1a recombinant protein
[Similar Products]
Product Synonym Gene Name
Cc2d1a[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q66HA5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cc2d1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Cc2d1a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001013891.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001013869.1
[Other Products]
UniProt Primary Accession #
Q66HA5
[Other Products]
UniProt Related Accession #
Q66HA5[Other Products]
Molecular Weight
98,618 Da
NCBI Official Full Name
coiled-coil and C2 domain-containing protein 1A
NCBI Official Synonym Full Names
coiled-coil and C2 domain containing 1A
NCBI Official Symbol
Cc2d1a [Similar Products]
NCBI Official Synonym Symbols
RGD1306108
[Similar Products]
NCBI Protein Information
coiled-coil and C2 domain-containing protein 1A
UniProt Protein Name
Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names
Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1
Protein Family
Coiled-coil and C2 domain-containing protein
UniProt Gene Name
Cc2d1a [Similar Products]
UniProt Synonym Gene Names
FRE under dual repression-binding protein 1; Freud-1 [Similar Products]
UniProt Comments for Cc2d1a
Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses ().
Research Articles on Cc2d1a
1. Freud-1 and Freud-2 levels were different in rats selectively bred for 85 generations for either high level of fear-induced aggression or its absence. Freud-1 protein level was decreased in the hippocampus, whereas Freud-2 protein level was increased in the frontal cortex of highly aggressive rats. There no differences in 5-HT1A receptor gene expression were found in the brains of highly aggressive and nonaggressive rats.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
