Full Product Name
Mouse Anti-SCP3 [10G11/7]
Product Synonym Names
choline phosphotransferase 1 antibody; chpt1 antibody; COR 1 antibody; COR1 antibody; MGC71888 antibody; RNASCP3 antibody; SCP 3 antibody; SCP-3 antibody; Sycp 3 antibody; Sycp3 antibody; SYCP3_HUMAN antibody; Synaptonemal complex protein 3 antibody
Product Gene Name
anti-SCP3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZU3
Species Reactivity
Hamster, Mouse, Zebrafish
Specificity
Synaptonemal Complex Protein 3 (SCP3; COR1)
Purity/Purification
Protein A
Form/Format
Purified antibody (from supernatant) containing PBS + 0.02% sodium azide
Concentration
1mg/ml (lot specific)
Immunogen
Hamster COR1/SCP3 protein (expressed as 6x His fusion in bacteria and purified on a Talon under denaturing conditions)
Myeloma/fusion Partners
Sp2/OAg.14
Other Notes
Small volumes of anti-SCP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SCP3 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-SCP3 antibody
Optimal antibody dilution should be determined by titration
NCBI/Uniprot data below describe general gene information for SCP3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001171420.1
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NCBI GenBank Nucleotide #
NM_001177949.1
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UniProt Primary Accession #
Q8IZU3
[Other Products]
UniProt Related Accession #
Q8IZU3[Other Products]
Molecular Weight
27,729 Da
NCBI Official Full Name
synaptonemal complex protein 3
NCBI Official Synonym Full Names
synaptonemal complex protein 3
NCBI Official Symbol
SYCP3 [Similar Products]
NCBI Official Synonym Symbols
COR1; SCP3; SPGF4
[Similar Products]
NCBI Protein Information
synaptonemal complex protein 3
UniProt Protein Name
Synaptonemal complex protein 3
UniProt Gene Name
SYCP3 [Similar Products]
UniProt Synonym Gene Names
SCP3; SCP-3 [Similar Products]
UniProt Entry Name
SYCP3_HUMAN
NCBI Summary for SCP3
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
UniProt Comments for SCP3
SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family.
Chromosomal Location of Human Ortholog: 12q
Cellular Component: chromosome; nucleus
Molecular Function: DNA binding
Biological Process: male meiosis I; cell division; spermatogenesis, exchange of chromosomal proteins
Disease: Spermatogenic Failure 4
Product References and Citations for anti-SCP3 antibody
Tarsounas et al. 2004. Cell. 117:337-47. PMID: 15109494
Research Articles on SCP3
1. The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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