Product Name
SCP3 (SYCP3), Polyclonal Antibody
Full Product Name
Anti-SCP3 Antibody
Product Synonym Names
SCP3; Synaptonemal complex protein 3; SCP-3
Product Gene Name
anti-SYCP3 antibody
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Antibody/Peptide Pairs
SCP3 peptide (MBS8247869) is used for blocking the activity of SCP3 antibody (MBS8248157)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZU3
Species Reactivity
Human, Bovine, Monkey
Specificity
Recognizes endogenous levels of SCP3 protein.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SCP3. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SYCP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SYCP3 antibody
Rabbit polyclonal antibody to SCP3
Applications Tested/Suitable for anti-SYCP3 antibody
Western Blot (WB)
Application Notes for anti-SYCP3 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-SYCP3 antibody
Western blot analysis of SCP3 expression in K562 (A), 22RV1 (B), H480 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for SYCP3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001171419.1
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NCBI GenBank Nucleotide #
NM_001177948.1
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UniProt Primary Accession #
Q8IZU3
[Other Products]
UniProt Related Accession #
Q8IZU3[Other Products]
Molecular Weight
27,729 Da
NCBI Official Full Name
synaptonemal complex protein 3
NCBI Official Synonym Full Names
synaptonemal complex protein 3
NCBI Official Symbol
SYCP3 [Similar Products]
NCBI Official Synonym Symbols
COR1; SCP3; SPGF4; RPRGL4
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NCBI Protein Information
synaptonemal complex protein 3
UniProt Protein Name
Synaptonemal complex protein 3
Protein Family
Synaptonemal complex protein
UniProt Gene Name
SYCP3 [Similar Products]
UniProt Synonym Gene Names
SCP3; SCP-3 [Similar Products]
UniProt Entry Name
SYCP3_HUMAN
NCBI Summary for SYCP3
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
UniProt Comments for SYCP3
SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family.
Chromosomal Location of Human Ortholog: 12q
Cellular Component: lateral element; nucleus
Biological Process: spermatogenesis, exchange of chromosomal proteins
Disease: Spermatogenic Failure 4
Research Articles on SYCP3
1. SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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