Usher syndrome 2A (autosomal recessive, mild), ELISA Kit

Mouse Usherin (USH2A) ELISA kit; RP39; US2; USH2; dJ1111A8.1; usherin; Usher syndrome 2A (autosomal recessive; mild)

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

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Small volumes of USH2A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9319794 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Usher syndrome 2A (autosomal recessive, mild) (USH2A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing USH2A. The ELISA analytical biochemical technique of the MBS9319794 kit is based on USH2A antibody-USH2A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect USH2A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, USH2A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of USH2A (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

569,660 Da

Usher syndrome 2A (autosomal recessive, mild)

usherin; usher syndrome type-2A protein homolog; usher syndrome type IIa protein homolog; Usher syndrome 2A (autosomal recessive, mild) homolog

Usherin

Gm676  [Similar Products]

USH2A_MOUSE

USH2A: Involved in hearing and vision. Defects in USH2A are the cause of Usher syndrome type 2A (USH2A). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Defects in USH2A are the cause of retinitis pigmentosa type 39 (RP39). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP39 inheritance is autosomal recessive. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: photoreceptor inner segment; extracellular region; integral to membrane; terminal button; stereocilium; cell projection; stereocilium bundle; cell soma; membrane; cytoplasm; apical plasma membrane; plasma membrane; basement membrane; synapse; photoreceptor connecting cilium

Molecular Function: collagen binding; protein binding; myosin binding

Biological Process: sensory perception of sound; visual perception; inner ear receptor cell differentiation; sensory perception of light stimulus; response to stimulus; photoreceptor cell maintenance; maintenance of organ identity

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