Full Product Name
Anti-AMH Antibody
Product Synonym Names
AMH; anti Mullerian hormone; MIF; MIS
Product Gene Name
anti-AMH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P03971
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Immunogen
Anti-Mullerian hormone
Preparation and Storage
Store at -20 degree C for 24 months. Avoid repeated freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-AMH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AMH antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AMH antibody
IHC: 1:20-1:200
IF: 1:20-1:200
Immunohistochemistry (IHC) of anti-AMH antibody
Immunohistochemistry of paraffin-embedded human ovary tissue slide using (AMH Antibody) at dilution of 1:100
NCBI/Uniprot data below describe general gene information for AMH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000470.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000479.4
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UniProt Primary Accession #
P03971
[Other Products]
UniProt Related Accession #
P03971[Other Products]
NCBI Official Full Name
muellerian-inhibiting factor preproprotein
NCBI Official Synonym Full Names
anti-Mullerian hormone
NCBI Official Symbol
AMH [Similar Products]
NCBI Official Synonym Symbols
MIF; MIS
[Similar Products]
NCBI Protein Information
muellerian-inhibiting factor
UniProt Protein Name
Muellerian-inhibiting factor
UniProt Synonym Protein Names
Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance
Protein Family
Muellerian-inhibiting factor
UniProt Gene Name
AMH [Similar Products]
UniProt Synonym Gene Names
MIF; AMH; MIS [Similar Products]
UniProt Entry Name
MIS_HUMAN
NCBI Summary for AMH
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a
biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in ***** females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
UniProt Comments for AMH
AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; cytoplasm; extracellular region
Molecular Function: growth factor activity; hormone activity; transforming growth factor beta receptor binding; receptor binding
Biological Process: response to drug; sex determination; Mullerian duct regression; cell-cell signaling; gonadal mesoderm development; preantral ovarian follicle growth; sex differentiation; response to organic cyclic substance; urogenital system development; activation of NF-kappaB transcription factor; aging
Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
Research Articles on AMH
1. Women with higher testosterone and AMH had more frequent anovulatory cycles but there were marginal impacts on time to pregnancy or pregnancy loss.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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