Product Name
(Rhesus macaque) Myc proto-oncogene protein (MYC), Recombinant Protein
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) Myc proto-oncogene protein (MYC)
Product Synonym Names
Recombinant (Rhesus macaque) Myc proto-oncogene protein (MYC); Myc proto-oncogene protein; Proto-oncogene c-Myc Transcription factor p64
Product Gene Name
MYC recombinant protein
[Similar Products]
Product Synonym Gene Name
MYC[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SPRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN DSSSPKSCAS PDSSAFSPSS DSLLSSTESS PQASPEPLVL HEETPPTTSS DSEEEQEEEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAEE QKLISEKDLL RKRREQLKHK LEQLRNSCA
Chromosome Location
Chromosome: 8; NC_007865.1 (130351288..130353974). Location: chromosome: 8
3D Structure
ModBase 3D Structure for B8XIA5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MYC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001136345.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001142873.1
[Other Products]
UniProt Primary Accession #
B8XIA5
[Other Products]
UniProt Related Accession #
B8XIA5[Other Products]
Molecular Weight
48,800 Da[Similar Products]
NCBI Official Full Name
myc proto-oncogene protein
NCBI Official Symbol
MYC [Similar Products]
NCBI Official Synonym Symbols
c-Myc
[Similar Products]
NCBI Protein Information
myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Proto-oncogene c-Myc; Transcription factor p64
Protein Family
Myc protein
UniProt Gene Name
MYC [Similar Products]
UniProt Entry Name
MYC_MACMU
UniProt Comments for MYC
Function: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes
By similarity.
Subunit structure: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7
By similarity. Interacts with PIM2
By similarity. Interacts with NO66
By similarity.
Subcellular location: Nucleus › nucleoplasm
By similarity. Nucleus › nucleolus
By similarity.
Post-translational modification: Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome
By similarity. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC. Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence
By similarity.Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRUSS) complex
By similarity.
Involvement in disease: Note=Overexpression of C-Myc is implicated in the etiology of a variety of hematopoietic tumors.
Biotechnological use: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.2
Sequence similarities: Contains 1 bHLH (basic helix-loop-helix) domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
