14-3-3 gamma, Polyclonal Antibody

1433G; 143G; KCIP-1; Protein kinase C inhibitor protein-1, gamma polypeptide

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

14-3-3 gamma Antibody detects endogenous levels of 14-3-3 gamma

Affinity Chromatography

Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.

Small volumes of anti-YWHAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Induce target protein conformational changes that modify target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in development and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform different functions despite their sequence similarities.

Western Blot (WB), Flow Cytometry (FC/FACS)

WB: 1:1000-1:2000
FC/FACS: 1:50

Western blot analysis of 14-3-3 gamma expression in HeLa cell lysate.

28kDa

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

14-3-3 protein gamma

14-3-3 protein gamma

KCIP-1  [Similar Products]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

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