Full Product Name
Anti-CPS1 Rabbit pAb
Product Gene Name
anti-CPS1 antibody
[Similar Products]
Product Synonym Gene Name
Cps1; CPSase 1; CPSase I; CPSASE1; MS738[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31327
Species Reactivity
Human, Mouse, Rat
Specificity
CPS1 Antibody detects endogenous levels of total CPS1
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human CPS1
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-CPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CPS1 antibody
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Applications Tested/Suitable for anti-CPS1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes for anti-CPS1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50
Western Blot (WB) of anti-CPS1 antibody
Western blot analysis of CPS1 expression in HeLa cell lysate.
NCBI/Uniprot data below describe general gene information for CPS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116105.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001122633.2
[Other Products]
UniProt Primary Accession #
P31327
[Other Products]
UniProt Secondary Accession #
O43774; Q53TL5; Q59HF8; Q7Z5I5; B7Z818; J3KQL0[Other Products]
UniProt Related Accession #
P31327[Other Products]
NCBI Official Full Name
carbamoyl-phosphate synthase
NCBI Official Synonym Full Names
carbamoyl-phosphate synthase 1
NCBI Official Symbol
CPS1 [Similar Products]
NCBI Official Synonym Symbols
PHN; CPSASE1
[Similar Products]
NCBI Protein Information
carbamoyl-phosphate synthase [ammonia], mitochondrial
UniProt Protein Name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
UniProt Synonym Protein Names
Carbamoyl-phosphate synthetase I; CPSase I
Protein Family
Carboxypeptidase
UniProt Gene Name
CPS1 [Similar Products]
UniProt Synonym Gene Names
CPSase I [Similar Products]
NCBI Summary for CPS1
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010]
UniProt Comments for CPS1
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Research Articles on CPS1
1. Allele and genotype frequencies of the p.Thr1406Asn polymorphism did not differ between the infants with and without NEC, but the minor A-allele was less frequent in the group of 64 infants with the combined outcome NEC or death before 34 weeks of corrected gestational age than in the infants without this outcome. A significant negative association of the A-allele with the combined outcome NEC or death was found.
Precautions
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Disclaimer
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