Product Name
STX11, cDNA Clone
Full Product Name
STX11 cDNA Clone
Product Gene Name
STX11 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaaagacc ggctagcaga acttctggac ttgtccaagc aatatgacca gcagttccca gacggggacg atgagtttga ctcgccccac gaggacatcg tgttcgagac ggaccacatc ctggagtccc tgtaccgaga catccgggac attcaggatg aaaaccagct gctggtggcc gacgtgaagc ggctgggaaa gcagaacgcc cgcttcctca cgtccatgcg gcgcctcagc agcatcaagc gcgacaccaa ctccatcgcc aaggccatca aggcccgggg cgaggtcatc cactgcaagc tgcgcgccat gaaggagctg agcgaggcgg ctgaggccca gcacggcccg cactcggcag tggcgcgcat ttcgcgggcg cagtacaacg cgctcaccct caccttccag cgcgccatgc acgactacaa ccaggccgag atgaagcagc gcgacaactg caagatccgc atccagcgcc agctggagat catgggcaag gaagtctcgg gcgaccagat cgaggacatg ttcgagcagg gtaagtggga cgtgttttcc gagaacttgc tggccgacgt gaagggcgcg cgggccgccc tcaacgagat cgagagccgc caccgcgaac tgctgcgcct ggagagccgc atccgcgacg tacacgagct cttcttgcag atggcggtgc tggtggagaa gcaggccgac accctgaacg tcatcgagct caacgtacaa aagacggtcg actacaccgg ccaggccaag gcgcaggtgc ggaaggccgt gcagtacgag gagaagaacc cctgccggac cctctgctgc ttctgctgtc cctgcctcaa gtag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of STX11 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for STX11. It may not necessarily be applicable to this product.
NCBI Accession #
BC033519
[Other Products]
UniProt Secondary Accession #
O75378; O95148; Q5TCL6; E1P598[Other Products]
UniProt Related Accession #
O75558[Other Products]
Molecular Weight
33,196 Da
NCBI Official Full Name
Homo sapiens syntaxin 11, mRNA
NCBI Official Synonym Full Names
syntaxin 11
NCBI Official Symbol
STX11 [Similar Products]
NCBI Official Synonym Symbols
FHL4; HLH4; HPLH4
[Similar Products]
NCBI Protein Information
syntaxin-11
UniProt Protein Name
Syntaxin-11
UniProt Gene Name
STX11 [Similar Products]
UniProt Entry Name
STX11_HUMAN
NCBI Summary for STX11
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
UniProt Comments for STX11
STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.
Chromosomal Location of Human Ortholog: 6q24.2
Cellular Component: integral to membrane; plasma membrane; SNARE complex; synaptic vesicle
Molecular Function: protein binding; SNARE binding
Biological Process: intracellular protein transport; synaptic vesicle fusion to presynaptic membrane; vesicle docking
Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4
Research Articles on STX11
1. The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
