Full Product Name
STX11 Polyclonal Antibody
Product Synonym Names
FHL4; HLH4; HPLH4
Product Gene Name
anti-STX11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.6mg/mL (lot specific)
Immunogen
Recombinant protein of human STX11
Calculated Molecular Weight: 33kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-STX11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-STX11 antibody
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.
Applications Tested/Suitable for anti-STX11 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-STX11 antibody
WB: 1:500-1:2000
IHC: 1:25-1:100
Western Blot (WB) of anti-STX11 antibody
Western Blot analysis of Mouse lung tissue using STX11 Polyclonal Antibody at dilution of 1:400
Immunohistochemistry (IHC) of anti-STX11 antibody
Immunohistochemistry of paraffin-embedded Human breast cancer using STX11 Polyclonal Antibody at dilution of 1:30
Immunohistochemistry (IHC) of anti-STX11 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer using STX11 Polyclonal Antibody at dilution of 1:30
NCBI/Uniprot data below describe general gene information for STX11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003755.2
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NCBI GenBank Nucleotide #
NM_003764.3
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UniProt Secondary Accession #
O75378; O95148; Q5TCL6; E1P598[Other Products]
UniProt Related Accession #
O75558[Other Products]
Molecular Weight
33,196 Da
NCBI Official Full Name
syntaxin-11
NCBI Official Synonym Full Names
syntaxin 11
NCBI Official Symbol
STX11 [Similar Products]
NCBI Official Synonym Symbols
FHL4; HLH4; HPLH4
[Similar Products]
NCBI Protein Information
syntaxin-11
UniProt Protein Name
Syntaxin-11
UniProt Gene Name
STX11 [Similar Products]
UniProt Entry Name
STX11_HUMAN
NCBI Summary for STX11
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
UniProt Comments for STX11
STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.
Chromosomal Location of Human Ortholog: 6q24.2
Cellular Component: SNARE complex; Golgi apparatus; synaptic vesicle; integral to membrane; plasma membrane; endomembrane system
Molecular Function: SNAP receptor activity; SNARE binding; protein binding
Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; vesicle docking; natural killer cell degranulation; neutrophil degranulation; cytotoxic T cell degranulation
Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4
Research Articles on STX11
1. Stx11 functions as a t-SNARE for the final fusion of LG at the IS.
Precautions
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Disclaimer
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