syntaxin 11, ELISA Kit

Human Syntaxin-11 (STX11) ELISA kit; FHL4; HLH4; HPLH4; ; syntaxin 11

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of STX11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9339970 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the syntaxin 11 (STX11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STX11. The ELISA analytical biochemical technique of the MBS9339970 kit is based on STX11 antibody-STX11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STX11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STX11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

33,196 Da

syntaxin 11

syntaxin-11

Syntaxin-11

STX11_HUMAN

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.

Chromosomal Location of Human Ortholog: 6q24.2

Cellular Component: SNARE complex; Golgi apparatus; synaptic vesicle; plasma membrane; integral to membrane; endomembrane system

Molecular Function: SNAP receptor activity; protein binding; SNARE binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; vesicle docking; natural killer cell degranulation; neutrophil degranulation; cytotoxic T cell degranulation

Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4

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