Product Name
5-hydroxytryptamine receptor 1A (Htr1a), Recombinant Protein
Full Product Name
Recombinant Mouse 5-hydroxytryptamine receptor 1A (Htr1a)
Product Gene Name
Htr1a recombinant protein
[Similar Products]
Product Synonym Gene Name
Gpcr18[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-421aa; full length protein
Sequence
MDMFSLGQGN NTTTSLEPFG TGGNDTGLSN VTFSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSNPNECTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKKGAGT SFGTSSAPPP KKSLNGQPGS GDCRRSAENR AVGTPCANGA VRQGEDDATL EVIEVHRVGN SKGHLPLPSE SGATSYVPAC LERKNERTAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPEL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC R
3D Structure
ModBase 3D Structure for Q64264
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Htr1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Htr1a recombinant protein
Transmembrane Protein
Application Notes for Htr1a recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Htr1a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032334.2
[Other Products]
NCBI GenBank Nucleotide #
NM_008308.4
[Other Products]
UniProt Primary Accession #
Q64264
[Other Products]
UniProt Secondary Accession #
Q60956; Q61617; Q8BGS4[Other Products]
UniProt Related Accession #
Q64264[Other Products]
Molecular Weight
46,176 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 1A
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1A
NCBI Official Symbol
Htr1a [Similar Products]
NCBI Official Synonym Symbols
Gpcr18
[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 1A
UniProt Protein Name
5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names
Serotonin receptor 1A
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr1a [Similar Products]
UniProt Synonym Gene Names
Gpcr18; 5-HT-1A; 5-HT1A [Similar Products]
UniProt Entry Name
5HT1A_MOUSE
UniProt Comments for Htr1a
5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass
Cellular Component: axon hillock; cell soma; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: drug binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity
Biological Process: behavior; behavioral fear response; cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; regulation of behavior; regulation of dopamine metabolic process; regulation of hormone secretion; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; signal transduction; vasoconstriction
Research Articles on Htr1a
1. Results indicate that postsynaptic 5-HT1A receptors exert a modulatory function in food intake in free-feeding and fasted mice, which for the first time shows an involvement of postsynaptic 5-HT1A receptors in feeding behavior
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
