Full Product Name
FOXP1 Antibody
Product Synonym Names
12CC4; FLJ23741; HSPC215; MGC12942; MGC88572; MGC99551; QRF1; hFKH1B
Product Gene Name
anti-FOXP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of FOXP1
Calculated Molecular Weight: 114aa; 12kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31731 / sc-31736 / sc-66896
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FOXP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FOXP1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FOXP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001231745.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001244816.1
[Other Products]
UniProt Secondary Accession #
Q8NAN6; Q9BSG9; Q9H332; Q9H333; Q9P0R1; A3QVP8; B3KV70; G5E9V8[Other Products]
UniProt Related Accession #
Q9H334[Other Products]
Molecular Weight
77,249 Da
NCBI Official Full Name
forkhead box protein P1 isoform 1
NCBI Official Synonym Full Names
forkhead box P1
NCBI Official Symbol
FOXP1 [Similar Products]
NCBI Official Synonym Symbols
MFH; QRF1; 12CC4; hFKH1B; HSPC215
[Similar Products]
NCBI Protein Information
forkhead box protein P1; fork head-related protein like B; glutamine-rich factor 1; mac-1-regulated forkhead
UniProt Protein Name
Forkhead box protein P1
UniProt Synonym Protein Names
Mac-1-regulated forkhead
Protein Family
Forkhead box protein
UniProt Gene Name
FOXP1 [Similar Products]
UniProt Entry Name
FOXP1_HUMAN
NCBI Summary for FOXP1
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and *****hood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXP1
FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell cycle regulation; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; androgen receptor binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; osteoclast differentiation; endothelial cell activation; regulation of transcription from RNA polymerase II promoter; macrophage activation; regulation of monocyte differentiation; monocyte activation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of tumor necrosis factor production; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis
Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features
Research Articles on FOXP1
1. our results may suggest a possible broader role of FOXP1 in the pathogenesis and progression of myelodysplasia and acute myeloid leukemia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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