Product Name
SLC39A4, Polyclonal Antibody
Popular Item
Full Product Name
SLC39A4 Polyclonal Antibody
Product Synonym Names
AEZ; ZIP4; AWMS2
Product Gene Name
anti-SLC39A4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6P5W5
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human SLC39A4
Calculated Molecular Weight
68kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-SLC39A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC39A4 antibody
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-SLC39A4 antibody
Polyclonal
Applications Tested/Suitable for anti-SLC39A4 antibody
Western Blot (WB)
Application Notes for anti-SLC39A4 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-SLC39A4 antibody
Western blot analysis of extracts of various cell lines, using SLC39A4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Immunohistochemistry (IHC) of anti-SLC39A4 antibody
Immunohistochemistry of paraffin-embedded mouse lung using SLC39A4 antibody at dilution of 1:100 (40x lens).
NCBI/Uniprot data below describe general gene information for SLC39A4. It may not necessarily be applicable to this product.
NCBI Accession #
Q6P5W5.3
[Other Products]
UniProt Primary Accession #
Q6P5W5
[Other Products]
UniProt Secondary Accession #
Q7L5S5; Q9H6T8; Q9NXC4[Other Products]
UniProt Related Accession #
Q6P5W5[Other Products]
NCBI Official Full Name
Zinc transporter ZIP4
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 4
NCBI Official Symbol
SLC39A4 [Similar Products]
NCBI Official Synonym Symbols
AEZ; ZIP4; AWMS2
[Similar Products]
NCBI Protein Information
zinc transporter ZIP4; zrt- and Irt-like protein 4
UniProt Protein Name
Zinc transporter ZIP4
UniProt Synonym Protein Names
Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
Protein Family
Zinc transporter
UniProt Gene Name
SLC39A4 [Similar Products]
UniProt Synonym Gene Names
ZIP4; ZIP-4 [Similar Products]
UniProt Entry Name
S39A4_HUMAN
NCBI Summary for SLC39A4
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for SLC39A4
SLC39A4: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: recycling endosome membrane; cytoplasmic membrane-bound vesicle; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; transmembrane transport
Disease: Acrodermatitis Enteropathica, Zinc-deficiency Type
Research Articles on SLC39A4
1. Both acrodermatitis mutations cause absence of the ZIP4 transporter cell surface expression and nearly absent zinc uptake.
Precautions
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