Full Product Name
RFXAP (Regulatory Factor X Associated Protein, Regulatory Factor X-associated Protein, RFX-associated Protein, RFX DNA-binding Complex 36kD Subunit)
Product Synonym Names
Anti -RFXAP (Regulatory Factor X Associated Protein, Regulatory Factor X-associated Protein, RFX-associated Protein, RFX DNA-binding Complex 36kD Subunit)
Product Gene Name
anti-RFXAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MEAQSVAEGA GPGAASGVPH PAALAPAAAP TLAPASVAAA ASQFTLLVMQ PCAGQDEAAA PGGSVGAGKP VRYLCEGAGD GEEEAGEDEA DLLDTSDPPG GGESAASLED LEDEETHSGG EGSSGGARRR GSGGGSMSKT CTYEGCSETT SQVAKQRKPW MCKKHRNKMY KDKYKKKKSD QALNCGGTAS TGSAGNVKLE ESADNILSIV KQRTGSFGDR PARPTLLEQV LNQKRLSLLR SPEVVQFLQK QQQLLNQQVL EQRQQQFPGT SM
Chromosome Location
Chromosome: 13; NC_000013.10 (37393339..37403740). Location: 13q14
3D Structure
ModBase 3D Structure for O00287
Specificity
Recognizes human RFXAP.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human RFXAP, aa1-272 (AAH26088.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-RFXAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RFXAP antibody
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
Product Categories/Family for anti-RFXAP antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-RFXAP antibody
Western Blot (WB)
Application Notes for anti-RFXAP antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for RFXAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000529.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000538.3
[Other Products]
UniProt Primary Accession #
O00287
[Other Products]
UniProt Secondary Accession #
Q5VZM6; Q8TC40; B2R9T8[Other Products]
UniProt Related Accession #
O00287[Other Products]
Molecular Weight
28,232 Da[Similar Products]
NCBI Official Full Name
regulatory factor X-associated protein
NCBI Official Synonym Full Names
regulatory factor X-associated protein
NCBI Official Symbol
RFXAP [Similar Products]
NCBI Protein Information
regulatory factor X-associated protein; RFX-associated protein; RFX DNA-binding complex 36 kDa subunit
UniProt Protein Name
Regulatory factor X-associated protein
UniProt Synonym Protein Names
RFX DNA-binding complex 36 kDa subunit
Protein Family
Regulatory factor X-associated protein
UniProt Gene Name
RFXAP [Similar Products]
UniProt Synonym Gene Names
RFX-associated protein [Similar Products]
UniProt Entry Name
RFXAP_HUMAN
NCBI Summary for RFXAP
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for RFXAP
RFXAP: Part of the RFX complex that binds to the X-box of MHC II promoters. Defects in RFXAP are a cause of bare lymphocyte syndrome type 2 (BLS2); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13q14
Cellular Component: nucleus
Molecular Function: DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: positive regulation of transcription, DNA-dependent
Disease: Bare Lymphocyte Syndrome, Type Ii
Research Articles on RFXAP
1. RFXAP(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple.
Precautions
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Disclaimer
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