gamma-aminobutyric acid (GABA) A receptor, beta 1, ELISA Kit

Human Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) ELISA kit; gamma-aminobutyric acid (GABA) A receptor; beta 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GABRB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9324635 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GABRB1. The ELISA analytical biochemical technique of the MBS9324635 kit is based on GABRB1 antibody-GABRB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABRB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABRB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

54,235 Da

gamma-aminobutyric acid (GABA) A receptor, beta 1

gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor, beta 1; GABA(A) receptor subunit beta-1; gamma-aminobutyric acid A receptor beta 1

Gamma-aminobutyric acid receptor subunit beta-1

GBRB1_HUMAN

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]

GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.

Protein type: Transporter; Membrane protein, integral; Channel, chloride; Channel, ligand-gated; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; ion transport; signal transduction; transmembrane transport

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