Product Name
Cytokeratin 2e (KRT2), Monoclonal Antibody
Full Product Name
Cytokeratin 2e antibody
Product Synonym Names
Monoclonal Cytokeratin 2e; Anti-Cytokeratin 2e; Cytokeratin e 2; Cytokeratin e -2; Cytokeratin 2e; Keratin K2
Product Gene Name
anti-KRT2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35908
Clone Number
Ks 2.342.7.4
Species Reactivity
Human cytokeratin 2e
Purity/Purification
Culture supernatant
Form/Format
Hybridoma culture supernatant with 0.09% NaN3.
Biological Significance
Keratins are the major gene product of keratinocytes and form the intermediate filament cytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 are expressed. Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2E is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner.
Immunogen
Cytokeratin 2e antibody was raised in mouse using a synthetic peptide (N-terminal amino acids 2-23) of human cytokeratin 2e as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-KRT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT2 antibody
Mouse monoclonal Cytokeratin 2e antibody
Product Categories/Family for anti-KRT2 antibody
Cell Biology
Applications Tested/Suitable for anti-KRT2 antibody
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-KRT2 antibody
IF: 1:200
IHC-F: 1:100
IHC-P: 1:100
WB: 1:60.000
NCBI/Uniprot data below describe general gene information for KRT2. It may not necessarily be applicable to this product.
NCBI Accession #
EHH66304.1
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UniProt Primary Accession #
P35908
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UniProt Secondary Accession #
Q4VAQ2[Other Products]
Molecular Weight
65,433 Da[Similar Products]
NCBI Official Full Name
Cytokeratin-2e
UniProt Protein Name
Keratin, type II cytoskeletal 2 epidermal
UniProt Synonym Protein Names
Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2
UniProt Gene Name
KRT2 [Similar Products]
UniProt Synonym Gene Names
KRT2A; KRT2E; CK-2e; K2e [Similar Products]
UniProt Entry Name
K22E_HUMAN
UniProt Comments for KRT2
K2: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: Golgi apparatus; extracellular space; intermediate filament cytoskeleton; membrane; keratin filament; cytoplasm; intermediate filament; nucleus
Molecular Function: structural constituent of cytoskeleton
Biological Process: epidermis development; keratinocyte activation; keratinization; keratinocyte proliferation; keratinocyte migration
Disease: Ichthyosis, Bullous Type
Precautions
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Disclaimer
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