Product Name
LDL-R (LDLR), Blocking Peptide
Full Product Name
LDL-R Peptide
Product Synonym Names
FH; FHC; LDLCQ2; Low-density lipoprotein receptor; LDL receptor; low density lipoprotein receptor
Product Gene Name
LDLR blocking peptide
[Similar Products]
LDL-R peptide (MBS153159) is used for blocking the activity of LDL-R antibody (MBS150298)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01130
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
18 amino acids near the center of human LDL-R.
Preparation and Storage
Store LDL-R peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of LDLR blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for LDLR blocking peptide
Blocking (BL)
Application Notes for LDLR blocking peptide
LDL-R peptide is used for blocking the activity of LDL-R antibody.
NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000518
[Other Products]
NCBI GenBank Nucleotide #
NM_000527.4
[Other Products]
UniProt Primary Accession #
P01130
[Other Products]
UniProt Secondary Accession #
Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7[Other Products]
UniProt Related Accession #
P01130[Other Products]
Molecular Weight
82,255 Da
NCBI Official Full Name
low-density lipoprotein receptor isoform 1
NCBI Official Synonym Full Names
low density lipoprotein receptor
NCBI Official Symbol
LDLR [Similar Products]
NCBI Official Synonym Symbols
FH; FHC; LDLCQ2
[Similar Products]
NCBI Protein Information
low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3
UniProt Protein Name
Low-density lipoprotein receptor
Protein Family
Low-density lipoprotein receptor
UniProt Gene Name
LDLR [Similar Products]
UniProt Synonym Gene Names
LDL receptor [Similar Products]
UniProt Entry Name
LDLR_HUMAN
NCBI Summary for LDLR
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
UniProt Comments for LDLR
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell surface; Receptor, misc.
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: Golgi apparatus; cell surface; membrane; integral to plasma membrane; lysosome; late endosome; early endosome; plasma membrane; endosome membrane; coated pit; receptor complex; external side of plasma membrane
Molecular Function: very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding
Biological Process: phototransduction, visible light; cholesterol metabolic process; lipoprotein catabolic process; receptor-mediated endocytosis; cholesterol homeostasis; cholesterol transport; viral reproduction; cholesterol absorption; phospholipid transport; lipoprotein metabolic process; endocytosis; lipid metabolic process; retinoid metabolic process
Disease: Hypercholesterolemia, Familial
Research Articles on LDLR
1. LDLR rs2228671-T allele frequency was rare.
Precautions
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Disclaimer
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