Full Product Name
BLM (phospho Thr99) Polyclonal Antibody
Product Gene Name
anti-BLM antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54132
Other Notes
Small volumes of anti-BLM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BLM. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000048.1
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NCBI GenBank Nucleotide #
NM_000057.3
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UniProt Primary Accession #
P54132
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UniProt Secondary Accession #
Q52M96[Other Products]
UniProt Related Accession #
P54132[Other Products]
Molecular Weight
159,000 Da
NCBI Official Full Name
Bloom syndrome protein isoform 1
NCBI Official Synonym Full Names
Bloom syndrome RecQ like helicase
NCBI Official Symbol
BLM [Similar Products]
NCBI Official Synonym Symbols
BS; RECQ2; RECQL2; RECQL3
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NCBI Protein Information
Bloom syndrome protein
UniProt Protein Name
Bloom syndrome protein
UniProt Synonym Protein Names
DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3
Protein Family
Bloom syndrome protein
UniProt Gene Name
BLM [Similar Products]
UniProt Synonym Gene Names
RECQ2; RECQL3; RecQ2 [Similar Products]
NCBI Summary for BLM
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
UniProt Comments for BLM
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030).
Research Articles on BLM
1. Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function.
Precautions
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Disclaimer
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