Product Name
Chordin-like protein 2 (CHRDL2), Recombinant Protein
Full Product Name
Recombinant Human Chordin-like protein 2 (CHRDL2)
Product Gene Name
CHRDL2 recombinant protein
[Similar Products]
Product Synonym Gene Name
CHRDL2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
26-429aa, Full Length of Mature Protein
Sequence
RARPDMFCLF HGKRYSPGES WHPYLEPQGL MYCLRCTCSE GAHVSCYRLH CPPVHCPQPV TEPQQCCPKC VEPHTPSGLR APPKSCQHNG TMYQHGEIFS AHELFPSRLP NQCVLCSCTE GQIYCGLTTC PEPGCPAPLP LPDSCCQACK DEASEQSDEE DSVQSLHGVR HPQDPCSSDA GRKRGPGTPA PTGLSAPLSF IPRHFRPKGA GSTTVKIVLK EKHKKACVHG GKTYSHGEVW HPAFRAFGPL PCILCTCEDG RQDCQRVTCP TEYPCRHPEK VAGKCCKICP EDKADPGHSE ISSTRCPKAP GRVLVHTSVS PSPDNLRRFA LEHEASDLVE IYLWKLVKGI FHLTQIKKVR KQDFQKEAQH FRLLAGPHEG HWNVFLAQTL ELKVTASPDK VTKT
3D Structure
ModBase 3D Structure for Q6WN34
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CHRDL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHRDL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001265402.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001278473.2
[Other Products]
UniProt Primary Accession #
Q6WN34
[Other Products]
UniProt Secondary Accession #
Q6WN30; Q6WN31; Q6WN32; Q7Z5J3; A5PKU9[Other Products]
UniProt Related Accession #
Q6WN34[Other Products]
Molecular Weight
9,846 Da
NCBI Official Full Name
chordin-like protein 2 isoform 2
NCBI Official Synonym Full Names
chordin like 2
NCBI Official Symbol
CHRDL2 [Similar Products]
NCBI Official Synonym Symbols
BNF1; CHL2
[Similar Products]
NCBI Protein Information
chordin-like protein 2
UniProt Protein Name
Chordin-like protein 2
UniProt Synonym Protein Names
Breast tumor novel factor 1; BNF-1; Chordin-related protein 2
Protein Family
Chordin-like protein
UniProt Gene Name
CHRDL2 [Similar Products]
UniProt Synonym Gene Names
BNF1; CHL2; BNF-1 [Similar Products]
NCBI Summary for CHRDL2
This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in ***** cartilage regeneration. [provided by RefSeq, Jan 2015]
UniProt Comments for CHRDL2
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Research Articles on CHRDL2
1. These results suggest CHRDL2 could serve as a biomarker of poor prognosis in CRC, and provide evidence that CHRDL2 acts as an oncogene in human colorectal cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
