Full Product Name
POLG Antibody, FITC conjugated
Product Synonym Names
DNA polymerase subunit gamma-1, mitochondrial DNA polymerase catalytic subunit; PolG-alpha; POLG; MDP1; POLG1; POLGA
Product Gene Name
anti-POLG antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54098
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human DNA polymerase subunit gamma-1 protein (446-590AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-POLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-POLG antibody
Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
Product Categories/Family for anti-POLG antibody
Epigenetics and Nuclear Signaling; Metabolism
Applications Tested/Suitable for anti-POLG antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for POLG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001119603.1
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NCBI GenBank Nucleotide #
NM_001126131.1
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UniProt Primary Accession #
P54098
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UniProt Secondary Accession #
Q8N***; Q92515[Other Products]
UniProt Related Accession #
P54098[Other Products]
Molecular Weight
139,562 Da
NCBI Official Full Name
DNA polymerase subunit gamma-1
NCBI Official Synonym Full Names
DNA polymerase gamma, catalytic subunit
NCBI Official Symbol
POLG [Similar Products]
NCBI Official Synonym Symbols
PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B
[Similar Products]
NCBI Protein Information
DNA polymerase subunit gamma-1
UniProt Protein Name
DNA polymerase subunit gamma-1
UniProt Synonym Protein Names
Mitochondrial DNA polymerase catalytic subunit; PolG-alpha
Protein Family
DNA polymerase
UniProt Gene Name
POLG [Similar Products]
UniProt Synonym Gene Names
MDP1; POLG1; POLGA [Similar Products]
NCBI Summary for POLG
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for POLG
Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
Research Articles on POLG
1. This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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