Keratin, type II cytoskeletal 2 epidermal, ELISA Kit

Keratin, type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2; KRT2; KRT2A; KRT2E

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of KRT2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2883744 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Keratin, type II cytoskeletal 2 epidermal (KRT2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KRT2. The ELISA analytical biochemical technique of the MBS2883744 kit is based on KRT2 antibody-KRT2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KRT2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KRT2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

65,433 Da

keratin 2, type II

keratin, type II cytoskeletal 2 epidermal

Keratin, type II cytoskeletal 2 epidermal

KRT2A; KRT2E; CK-2e; K2e  [Similar Products]

K22E_HUMAN

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

K2: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoplasm; extracellular space; Golgi apparatus; intermediate filament; intermediate filament cytoskeleton; keratin filament; membrane; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; keratinization; keratinocyte activation; keratinocyte migration; keratinocyte proliferation

Disease: Ichthyosis, Bullous Type

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