Full Product Name
CRDL2 Polyclonal Antibody
Product Synonym Names
Chordin-like protein 2; Breast tumor novel factor 1; BNF-1; Chordin-related protein 2; CHRDL2; BNF1; CHL2; UNQ765/PRO1557
Product Gene Name
anti-CRDL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6WN34
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 330-410
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CRDL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CRDL2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CRDL2 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CRDL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001265402.1
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NCBI GenBank Nucleotide #
NM_001278473.2
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UniProt Primary Accession #
Q6WN34
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UniProt Secondary Accession #
Q6WN30; Q6WN31; Q6WN32; Q7Z5J3; A5PKU9[Other Products]
UniProt Related Accession #
Q6WN34[Other Products]
NCBI Official Full Name
chordin-like protein 2 isoform 2
NCBI Official Synonym Full Names
chordin like 2
NCBI Official Symbol
CHRDL2 [Similar Products]
NCBI Official Synonym Symbols
BNF1; CHL2
[Similar Products]
NCBI Protein Information
chordin-like protein 2
UniProt Protein Name
Chordin-like protein 2
UniProt Synonym Protein Names
Breast tumor novel factor 1; BNF-1; Chordin-related protein 2
UniProt Gene Name
CHRDL2 [Similar Products]
UniProt Synonym Gene Names
BNF1; CHL2; BNF-1 [Similar Products]
NCBI Summary for CRDL2
This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in ***** cartilage regeneration. [provided by RefSeq, Jan 2015]
UniProt Comments for CRDL2
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Research Articles on CRDL2
1. These results suggest CHRDL2 could serve as a biomarker of poor prognosis in CRC, and provide evidence that CHRDL2 acts as an oncogene in human colorectal cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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