Product Name
AFG3L2, Polyclonal Antibody
Full Product Name
AFG3L2 antibody (HRP)
Product Synonym Names
Rabbit polyclonal AFG3L2 antibody (HRP); Polyclonal AFG3L2 antibody; Anti-AFG3L2 antibody; Paraplegin like protein antibody; AFG3L 2 antibody; AFG3L 2 antibody
Product Gene Name
anti-AFG3L2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y4W6
Purity/Purification
Purified by Ammonium Sulfate precipitation
Form/Format
Supplied with 0.03% Proclin 300, 50% Glycerol and 0.01M PBS, PH 7.4
Immunogen
AFG3L2 antibody (HRP) was raised in Rabbit using recombinant human AFG3-like protein 2 protein as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage and-20 degree C for long term storage.
Avoid repeat freeze/thaw cycles.
Other Notes
Small volumes of anti-AFG3L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AFG3L2 antibody
AFG3L2 is a candidate gene for hereditary spastic paraplegias and neurodegenerative disorders and is a putative ATP dependent protease.
Product Categories/Family for anti-AFG3L2 antibody
Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-AFG3L2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for AFG3L2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006787.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006796.2
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UniProt Primary Accession #
Q9Y4W6
[Other Products]
UniProt Secondary Accession #
Q6P1L0[Other Products]
UniProt Related Accession #
Q9Y4W6[Other Products]
Molecular Weight
88,584 Da
NCBI Official Full Name
AFG3-like protein 2
NCBI Official Synonym Full Names
AFG3 like matrix AAA peptidase subunit 2
NCBI Official Symbol
AFG3L2 [Similar Products]
NCBI Official Synonym Symbols
SCA28; SPAX5
[Similar Products]
NCBI Protein Information
AFG3-like protein 2
UniProt Protein Name
AFG3-like protein 2
UniProt Synonym Protein Names
Paraplegin-like protein
Protein Family
AFG3-like protein
UniProt Gene Name
AFG3L2 [Similar Products]
NCBI Summary for AFG3L2
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008]
UniProt Comments for AFG3L2
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form ().
Research Articles on AFG3L2
1. Deletion of AFG3L2 associated with spinocerebellar ataxia type 28 in the context of multiple genomic anomalies.
Precautions
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Disclaimer
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