5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, ELISA Kit

Mus musculus; Mouse; 5; 6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Brown locus protein; Catalase B; Tyrosinase-related protein 1; TRP; TRP-1; TRP1; Tyrp1; Tyrp-1; 1.14.18.-

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of Tyrp1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9428879 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase (Tyrp1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Tyrp1. The ELISA analytical biochemical technique of the MBS9428879 kit is based on Tyrp1 antibody-Tyrp1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Tyrp1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Tyrp1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

60,761 Da

tyrosinase-related protein 1

5,6-dihydroxyindole-2-carboxylic acid oxidase

5,6-dihydroxyindole-2-carboxylic acid oxidase

Tyrp-1; DHICA oxidase; TRP; TRP-1; TRP1  [Similar Products]

TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 4 C3|4 37.89 cM

Cellular Component: endosome membrane; melanosome; melanosome membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: acetoacetic acid metabolic process; melanin biosynthetic process from tyrosine; melanin metabolic process; melanocyte differentiation; melanosome organization and biogenesis; pigmentation; positive regulation of melanin biosynthetic process

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